Burkitt lymphoma

Burkitt-lymphoma-T2-T1-POST_small1.jpg

Image 1

Clinical History: 
An eight year old boy.

Diagnosis:
Burkitt lymphoma

MR Technique: 
4 mm axial pre-contrast T2- and post-contrast GRE (FLASH) T1-weighted images are presented, acquired at 3 T on a Siemens TimTrio MR system. Sequence parameters were TR/ TE = 4000/135 and 250/2.5 respectively.

Imaging Findings:
There is a large left parapharyngeal space mass. There is decreased SI centrally within the lesion on the T2-weighted scan, with a lack of enhancement in the corresponding region on the post-contrast T1-weighted scan, consistent with central necrosis. In terms of histopathology, the appearance of the lesion on imaging is non-specific, other than its location.

Burkitt lymphoma is a type of non-Hodgkin lymphoma. It is highly aggressive, rare, and has a strong male preponderance. The human immunodeficiency virus (HIV), which causes AIDS, has also been linked to the development of Burkitt lymphoma. The immunodeficiency-associated variant of this tumor is most common in HIV positive patients, but can also be seen in any immunosuppressed patient. It accounts for 30-40% of NHL in HIV patients, and is one of the AIDS defining diseases, being associated with the initial disease presentation.