First Experiences with the World’s First MAGNETOM Vida

This review focuses on 8 critical questions regarding gadolinium deposition in the brain and body, with the answers and discussion therein important for future regulatory decisions and clinical practice. [...]

Assessing Brain Volumes Using MorphoBox Prototype

This review focuses on 8 critical questions regarding gadolinium deposition in the brain and body, with the answers and discussion therein important for future regulatory decisions and clinical practice. [...]

High-resolution, Anatomically-accurate Diffusion-weighted Imaging of Orbital and Sinonasal Lesions with RESOLVE

This paper reviews four recently published studies where RESOLVE was shown to be clinically effective in the diffusion-weighted imaging of sinonasal and optic pathologies. It also demonstrates the clinical value that RESOLVE brings to the detection and characterization of the diseases in these regions. [...]

The Assessment of Endolymphatic Hydrops with High-resolution 3D Real Inversion Recovery and 3D Fluid Attenuated Inversion Recovery Sequences

Endolymphatic hydrops in patients with Meniere’s disease can be visualized using MR imaging. This article compares 3D SPACE FLAIR and 3D real IR in terms of the imaging results. [...]

Transurethral MR-Thermometry Guided Ultrasound Ablation of the Prostate – The Heidelberg Experience During Phase I of the TULSA-PRO Device Trial

This article describes a novel, MRI-guided, minimally-invasive method to safely ablate target benign and malignant prostate tissue with millimeter accuracy and precision. Real-time MR thermometry performed during transurethral ultrasound delivery enables active feedback control of the thermal volume, with high success in the ablation of the target tissue. [...]

Pearls Regarding the Use of MR Flow Techniques in Cerebrovascular Disease

Lecture: Pearls Regarding the Use of MR Flow Techniques in Cerebrovascular Disease [...]

A Safety Update on the Gadolinium Chelates

Lecture: A Safety Update on the Gadolinium Chelates [...]

syngo.MR Neuro 3D: Your All-In-One Post Processing, Visualization and Reporting Engine for BOLD Functional and Diffusion Tensor MR Imaging Datasets

Within this article, we have described our preferred workflow and steps for the processing and analysis of BOLD fMRI and DTI data. [...]

Further Customization of Dot Engines: AutoCoverage

This article details the steps to adjust and manipulate the coverage in the slice direction by using AutoCoverage available in many Dot AddIns. AutoCoverage is a powerful option, and will ensure that the complete anatomy will be covered in the underlying protocol. [...]

Biograph mMR System and Clincal Use Today

This article describes the latest technical and clinical developments for the Biograph mMR. Seminal publications in the field of neurology, cardiology, and oncology are discussed. [...]

Pictorial Essay: Pulmonary Imaging for Children

Especially in children with oncologic diseases that can be treated curatively, MRI can be used for the thoracic staging of the axillary, hilar, and mediastinal lymph nodes and to assess pulmonary metastases. The pictorial essay presents 5 cases. [...]

Multiparametric MRI at 3 Tesla for Prediction of Treatment Response in Rectal Cancer

The article describes the successful integration of a multiparametric MRI technique to monitor response to treatment in patients with rectal cancer. A voxel-by-voxel multiparametric analysis strategy has been adopted and early results show this is important in quantitatively assessing heterogeneity within the entire tumor region, and the changes in response to CRT in rectal cancer. [...]

Critical Questions Regarding Gadolinium Deposition in the Brain and Body After Injections of the Gadolinium-Based Contrast Agents, Safety, and Clinical Recommendations in Consideration of the EMA’s Pharmacovigilance and Risk Assessment Committee Recommendation for Suspension of the Marketing Authorizations for 4 Linear Agents

This review focuses on 8 critical questions regarding gadolinium deposition in the brain and body, with the answers and discussion therein important for future regulatory decisions and clinical practice. [...]

Safety of the Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging, Focusing in Part on Their Accumulation in the Brain and Especially the Dentate Nucleus

This review discusses first the background in terms of development of these agents and safety discussions therein, proceeds to a discussion of NSF and gadolinium deposition in the brain, and concludes with a discussion of the predictable future – specifically reassessment of the use of the linear GBCAs or a subset thereof. [...]

The Potential Role of Ultrashort Echo Time Sequences in MRI Guided Radiotherapy

This work shows the potential of ultra-short TE sequences to play an important role in MR guided Radiotherapy. Acquiring signal intensity at vastly reduced echo time opens up new imaging contrasts and many possibilities. [...]

Overview of Magnetic Resonance Fingerprinting

This overview of Magnetic Resonance Fingerprinting describes the basic concepts of MRF and illustrates some clinical applications. [...]

New ‘ADC & b-value’ Tool in syngo.via

This article describes the feature ‘ADC & computed b-value’ available on Siemens’ syngo.via VB10. This new tool provides an increased degree of freedom in the choice of the b-value for disease detection and characterization. [...]

MR-Guided Biopsies of the Prostate in Supine Patient Position

The article shows that targeted biopsies of the prostate under direct MRI-guidance are a reasonable complement to ultrasound biopsy techniques. The presented cases show that exact targeting of the most suspicious portion of a tumor is crucial for correct classification and consequently best therapy decisions. Especially in case of relatively small lesions, direct MR-guidance has clear advantages over fusion techniques. [...]

Pediatric Pathologies that have Leukocoria as Presenting Sign: the Podium

The article features the clinical and imaging signs and differential diagnosis of Retinoblastoma, persistent fetal vasculature and Coats’ disease. View/Download [...]

Application of Extracellular Gadolinium-based MRI Contrast Agents and the Risk of Nephrogenic Systemic Fibrosis

Presented is a review of nephrogenic systemic fibrosis and how this influences daily practice (in contrast enhanced magnetic resonance imaging), with specific clinical recommendations. Download PPTX-zip [...]

Accelerating Clinical MRI in the 21st Century

The established class of intravenous contrast media for magnetic resonance imaging is the gadolinium chelates, more generally referred to as the gadolinium-based contrast agents (GBCAs). [...]

Magnetic Resonance Imaging and Computed Tomography of the Brain – 50 Years of Innovation, With a Focus on the Future

The established class of intravenous contrast media for magnetic resonance imaging is the gadolinium chelates, more generally referred to as the gadolinium-based contrast agents (GBCAs). [...]

Safety of the Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging, Focusing in Part on Their Accumulation in the Brain and Especially the Dentate Nucleus

The established class of intravenous contrast media for magnetic resonance imaging is the gadolinium chelates, more generally referred to as the gadolinium-based contrast agents (GBCAs). [...]

Case Report: Clinical Usability of MyoMaps in Myocardial Infarction

These case reports show that current advances in T1 and T2 mapping and ECV quantification might have the potential to improve the diagnosis of cardiovascular disease, refine myocardial risk stratification and guide patient personalized therapeutic strategies. View/Download [...]

Cardiovascular Magnetic Resonance Teaching Network

The article introduces a novel teaching approach allowing time-effective teaching as well as an ongoing quality control. The aim is to enable CMR in all settings – hospitals of different sizes as well as in outpatient departments. [...]

Launch of the world’s first 7 T MR platform intended for clinical use (Siemens)

Erlangen, Germany, May 31, 2015 — Siemens announced at the Toronto ISMRM (International Society for Magnetic Resonance in Medicine) meeting the launch of the world’s first 7 T MR platform intended for clinical use. Important advances include a new, light, actively shielded magnet with zero helium boil-off and dual operating modes, enabling rapid switching between research […] [...]

CAIPIRINHA – Revisited

The development ofmulti coil receiver hardware as well as dedicated parallel acquisition techniques (PAT) and respective reconstruction methods allowed for a significant decrease of acquisition times in almost all clinical applications. This article provides a brief overview of 2D- and MS-CAIPIRINHA. [...]

Accelerated Diffusion Tensor Imaging of Skeletal Muscle Using Simultaneous Multi-Slice Acquisition

Simultaneous multi-slice acquisition with CAIPIRINHA reduces the scan time in diffusion-weighted MRI. In this article, early experience with this technique for accelerated DTI of skeletal muscle is shown. [...]

Simultaneous Multi-Slice (SMS) Imaging for Pre-Surgical BOLD fMRI and Diffusion Tractography: Case Illustrations

The presented case studies illustrate that SMS can increase the statistical confidence of fMRI and diffusion tractography results. These gains may be used to increase spatial image resolution and coverage, to improve spatial coregistration to high-resolution anatomical scans for intra-operative neuro-navigation, and / or to shorten acquisition times. [...]

Quiescent Interval Single-Shot (QISS) Lower Extremity MRA for the Diagnosis of Peripheral Artery Disease: Case Presentations

Case presentation of non-contrast QISS MRA providing high diagnostic accuracy for the detection of hemodynamically significant arterial stenosis of the lower extremities at both 1.5 and 3T. [...]

Point-of-Care MR Imaging and How We can Learn from Other Imaging Modalities. Thoughts on a Potential New Strategy

The article introduces point-of-care MRI, an extremely focused and goal-directed examinations strategy, that could reduce examination time and patient comfort. [...]

Simultaneous Multi-Slice (Slice Accelerated) Diffusion EPI: Early Experience for Brain Ischemia and Cervical Lymphadenopathy

In single shot EPI, the entirety of k-space is traversed after one shot (excitation). Readout-segmentation acquires k-space in multiple shots for reduced TE and encoding time. Real-time reacquisition of unusable shots is also supported. [...]

Clinical Case: 3 Tesla MR Neurography-Guided Posterior Femoral Cutaneous Nerve Block

The high SNR available at 3T provides the ability to perform high-resolution MR neurography-guided perineural injections for highly accurate visualization of small nerve as well as needle targeting and perineural injection. This case report demonstrates how this techniques facilitates accurate targeting of the PFCN.  Download/View PDF [...]

First Clinical Experiences with Simultaneous Multi-Slice Accelerated Diffusion-Weighted Imaging Throughout the Body

Dr. Valentin Tissot (CHRU, Brest, France) presents cases throughout the whole body that demonstrate that Simultaneous Multi-Slice (SMS) helps to accelerate diffusion-weighted imaging in almost all clinical cases where DWI is commonly applied. Robust results and good image quality can be achieved with an SMS factor of 2, which allows one to achieve near 2-fold acceleration. He also shows that ADC values are highly reproducible between the conventional and the accelerated technique. [...]

Iron Quantification with LiverLab

Liver iron content is an important clinical biomarker. Used with care, the R2c* values of the multi-echo Dixon VIBE in LiverLab allow estimating liver iron content. This article provides guidelines for the evaluation of liver iron. [...]

MR LiverLab

MR offers promising techniques for fat and iron evaluation in routine clinical liver diagnostics. This article shares the knowledge of implementing LiverLab, a comprehensive package which provides fat signal fraction (correlating with hepatic steatosis) and R2* of water (correlating with iron content). [...]

Compressed Sensing: a Paradigm Shift in MRI

In this article we share some of our experiences over the last few years with MR upgrades. [...]

syngo MR XA10 – Your New Work Environment for More Comfortable Scanning and Intuitive Image Processing

In this article we share some of our experiences over the last few years with MR upgrades. [...]

Case Series: Utilization of the Pediatric 16 Coil for 1.5T and 3T Systems

In this article we share some of our experiences over the last few years with MR upgrades. [...]

Case Series: Utilization of the Pediatric 16 Coil for 1.5T and 3T Systems

In this article we share some of our experiences over the last few years with MR upgrades. [...]

Long-term Experience with MR Upgrades

In this article we share some of our experiences over the last few years with MR upgrades. [...]

Rapid Estimation of Myelin for Diagnostic Imaging (REMyDI)

The article describes a new MRI myelin detection model to measure the presence of myelin by its effect on the surrounding cellular water, and discusses clinical applications of this technique. Download/View PDF [...]

fit-Upgrade: A Success Story

The fit-upgrade for 1.5 and 3T systems remains an economically attractive approach for an aged MR system. By improving system performance and workflow, the number of examinations can be increased, together with improved image quality, with little effort. Download/View PDF [...]

First Experiences with the Whole-Body Dot Engine

Whole-body MRI is beneficial in many clinical scenarios including bone marrow, infectious and rheumatic diseases. The Whole-Body Dot Engine provides fast and robust image quality across all patients, with fewer errors or need for repeated examinations. It ensures that all stations of a multi-station examination are performed with a consistent FOV and spatial resolution while […] [...]

Val M. Runge, MD – ASNR 2015 – Pearls and Pitfalls in Neuroradiology of Cerebrovascular Disease – The Essentials with MR and CT

This educational exhibit was presented at the ASNR 2015 meeting, with imaging performed on a 3 T Siemens Skyra MR system. The full reference for the exhibit is given below. Runge V, Smoker W, Valavanis A. Pearls and Pitfalls in Neuroradiology of Cerebrovascular Disease – The Essentials with MR and CT. ASNR 53rd Annual Meeting, […] [...]

Val M. Runge, MD – ASNR 2015 – Simultaneous Multi-Slice (Slice Accelerated) Diffusion EPI

This educational exhibit was presented at the ASNR 2015 meeting, with imaging performed on a 3 T Siemens Skyra MR system. The full reference for the exhibit is given below. Runge V, Richter J, Beck T, Piccirelli M, Valavanis A. Simultaneous Multi-Slice (Slice Accelerated) Diffusion EPI. ASNR 53rd Annual Meeting, April 25-30, 2015, Chicago, Illinois […] [...]

Val M. Runge, MD – Editorial – 50th anniversary issue of Investigative Radiology

ZURICH, May 12, 2015 — Val M. Runge, MD, editor-in-chief of Investigative Radiology, one of the world’s leading scientific journals in the field of imaging, previews in his editorial the upcoming anniversary issue of the journal. The 50th anniversary issue focuses on research (reflecting the very basis of the journal), specifically on the current top fields in clinical imaging, […] [...]

Val M. Runge, MD leads 50th anniversary issue of Investigative Radiology

ZURICH, April 6, 2015 /PRNewswire-iReach/ — Val M. Runge, MD, editor-in-chief of Investigative Radiology, one of the world’s leading scientific journals in the field of imaging, previews the upcoming anniversary issue of the journal. Scheduled to be published in September 2015, the issue includes 11 landmark articles, with the first already available on line (published ahead-of-print). (full […] [...]

Practical Considerations for the Evaluation of the Neuroforamina in Routine Spine Imaging at 3T. A Case Series

Pathologies of the neuroforamina are one of the most frequent indications for spine surgery. However, in standard MRI with axial and sagittal planes and relatively thick slices (>3 mm) the diagnostic information may be limited for proper evaluation of the nerve roots. Prof. Marc-André Weber et al. (University Hospital Heidelberg, Germany) share practical tips on […] [...]

Pelvic schwannoma

  Clinical History: 49-year old woman with an asymptomatic pelvic mass for 10 years (an incidental finding on routine physical examination)   Diagnosis: Pelvic schwannoma   MR Technique: Pelvic MR imaging was performed on a 3T system (Skyra, Siemens). (A) Coronal T2-weighted TIRM (TR/TE 4000/78ms), (B) sagittal T2-weighted TIRM (TR/TE 4000/70), (C) axial T1-weighted TSE […] [...]

Brain abscess

Clinical History: This 5-year old boy presented with an acute headache and vomiting for 12 hours. The patient had a clinical history of cholesteatoma surgery in the recent past, involving the right mastoid.   Diagnosis: Brain abscess   MR Technique: Contrast-enhanced brain MR imaging was performed on a 3T system following an unenhanced CT scan […] [...]

Proliferative myositis

  Clinical History: A 63-year old woman presents with an asymptomatic mass inferior to the right inguinal area for 10 days   Diagnosis: Proliferative myositis   MR Technique: Imaging of the right lower extremity was performed on a 3T MR system (Siemens Skyra). (A) Coronal T2-weighted TIRM (TR/TE 3000/38ms) and (B) axial T2-weighted TSE with […] [...]

Right renal angiomyolipoma

Clinical History: 59-year old woman with right lower back pain for more than one year   Diagnosis: Right renal angiomyolipoma   MR Technique: Upper abdominal imaging was performed on a 3T MR system. (A, B) Axial T1-weighted VIBE in- and out-of-phase (TR/TE 3.88/1.27ms), and (C) axial FS T2-weighted TSE (TR/TE 5814/78ms, with respiratory triggering) scans […] [...]

Left thigh schwannoma

  Clinical History: 31-year old woman with left foot numbness and pain for 6 months   Diagnosis: Left thigh schwannoma   MR Technique: Imaging of the left lower extremity was performed on a 3T MR system. (A) Coronal T2-weighted TIRM (TR/TE 3000/38ms), (B) sagittal T2-weighted TIRM (TR/TE 3000/38), (C) axial T1-weighted TSE (TR/TE 500/11) and […] [...]

Chronic osteomyelitis of the left femur

  Clinical History: An 11-year old boy with left thigh pain for 3 days   Diagnosis: Chronic osteomyelitis of the left femur   MR Technique: Imaging of the left lower extremity was performed on a 3T (Skyra) MR system. (A) Coronal T2-weighted TIRM (TR/TE 3000/38ms), (B) sagittal T2-weighted TIRM (TR/TE 2800/38), (C) axial T1-weighted TSE […] [...]

Prostatic sarcoma

        Clinical History: 25-year old man with dysuria for 3 weeks   Diagnosis: Prostatic sarcoma   MR Technique: Prostatic imaging was performed on a 3T MR system. (A) Sagittal T2-weighted TSE (TR/TE 7500/104ms), (B) coronal T2-weighted TSE (TR/TE 7354/104ms), and (C) axial T2-weighted TSE (TR/TE 7440/101) were acquired prior to the administration […] [...]

Cystosarcoma phyllodes of the breast (CSPB)

    Clinical history: 32-year old woman with a right breast mass   Diagnosis: Cystosarcoma phyllodes of the breast (CSPB)   Imaging techniques: Non-contrast MR imaging of the bilateral breasts was performed on a 3T MR system (Skyra, Siemens). (A) Axial T1-weighted TSE (TR/TE 626/8.1), (B) axial T2-weighted TSE with Dixon fat suppression (TR/TE 3700/101ms), […] [...]

Left thigh myxofibrosarcoma

  Clinical history: 52-year old man with left thigh mass   Diagnosis: Myxofibrosarcoma   Imaging techniques: Imaging of the left thigh was performed on a 3T MR system (Skyra, Siemens) and 64-MDCT (GE). (A) Coronal T2-weighted TIRM (TR/TE 3000/38), (B) sagittal T2-weighted TIRM (TR/TE 3000/38ms), (C) axial T1-weighted TSE (TR/TE 700/11ms), and (D) T2-weighted TSE […] [...]

Multiple myeloma

  Clinical History: 56-year old woman with right leg pain for 10 months   Diagnosis: Multiple myeloma   MR Technique: Imaging of the right lower extremity was performed on a 3T MR system. (A) Coronal T2-weighted TIRM (TR/TE 3000/38ms), (B) sagittal T2-weighted TIRM (TR/TE 3000/38), (C) axial T1-weighted TSE, and (D) axial T2-weighted TSE with […] [...]

Dermatofibrosarcoma protuberans

  Clinical history: 50-year old man with progressively enlarging left upper arm mass for one year   Diagnosis: Dermatofibrosarcoma protuberans   Imaging techniques: Imaging of the left upper arm was performed on a 3T MR system (Skyra, Siemens). (A) Coronal T2-weighted TIRM (TR/TE 2734/38), (B) axial T1-weighted TSE (TR/TE 500/12ms), and (C) axial T2-weighted TSE […] [...]

Intramuscular hemangioma

  Clinical History: 2-year old boy with an asymptomatic mass in his left buttock Diagnosis: Intramuscular hemangioma MR Technique: Imaging of the pelvis was performed on a 3T MR system (Skyra, Siemens). (A) Coronal T2-weighted TIRM (TR/TE 4000/78ms), (B) axial T1-weighted TSE (TR/TE 450/18ms), (C) axial FS T2-weighted TSE (TR/TE 2500/84ms), and (D) T2-weighted TIRM […] [...]

Thoracic spine schwannoma

  Clinical History: 28-year old woman with chest and upper back pain for 3 months Diagnosis: Thoracic spine schwannoma  MR Technique: Imaging of the thoracic spine was performed on a 3T MR system. (A) Sagittal T1-weighted TSE (TR/TE 650/8.1ms), (B) sagittal T2-weighted TSE (TR/TE 2000/97), (C) sagittal T2-weighted TSE images with Dixon fat suppression (TR/TE2500/101), […] [...]

Right thigh rhabdomyosarcoma

  Clinical history: 44-year old man with progressively enlarging right thigh mass Diagnosis: Rhabdomyosarcoma Imaging techniques: Imaging of the right thigh was performed on a 3T MR system (Skyra, Siemens). (A) Coronal T2-weighted TIRM (TR/TE 3000/38), (B) sagittal T2-weighted TIRM (TR/TE 3000/38ms), (C) axial T1-weighted TSE (TR/TE 700/12ms), and (D) T2-weighted TSE images with Dixon […] [...]

Oligodendroglioma

    Clinical history: 51-year old woman with episodic seizures for 20 years Diagnosis: Oligodendroglioma (WHO grade II) Imaging techniques: (A) Sagittal T1-weighted TIRM*(TR/TE 2000/9ms), (B) axial T1-weighted TIRM (TR/TE 2000/9ms), (C) axial T2-weighted TSE (TR/TE 4800/99ms), (D) axial T2-weighted TIRM (TR/TE 8500/85ms), and (E) coronal T2-weighted TIRM (TR/TE 8500/85ms) images were acquired along with […] [...]

Giant cell tumor

  Clinical History: 40 year old man with left knee pain for three months Diagnosis: Giant cell tumor involving the proximal tibia with intratumoral hemorrhage MR Technique: Knee imaging was performed on a 3T MR system (Skyra, Siemens). (A) Axial T1-weighted TSE (TR/TE 700/12ms) images and (B) axial T2-weighted TSE images with Dixon fat suppression […] [...]

Eosinophilic granuloma

Clinical History: 12 year old boy with back pain limiting activities of daily living Diagnosis: Thoracic vertebral eosinophilic granuloma MR Technique: Thoracic spine imaging was performed on a 3T MR system (Skyra, Siemens). (A) Sagittal T1-weighted TSE (TR/TE 650/8.1ms) and (B) T2-weighted TSE (TR/TE 2000/97ms) images were acquired. Contrast-enhanced sagittal T1-weighted (C) and coronal T1-weighted […] [...]

Intermuscular Lipoma

Clinical History: 46 year old woman with a progressively enlarging right thigh mass Diagnosis: Intermuscular lipoma of the anterior right thigh MR Technique: Imaging of the right thigh was performed on a 3T MR system (Skyra, Siemens). (A) Axial T1-weighted TSE (TR/TE 700/11ms) and (B, C) axial T2-weighted TSE water/fat-images obtained with the Dixon fat […] [...]

Burkitt lymphoma

An eight year old boy [...]

Colloid cyst

A 27-year-old woman who began to have headaches over the past 2 months, and then presented with significant nausea, vomiting, and lethargy [...]

Dandy-Walker variant

A 29 year old man with Down’s syndrome, and no acute clinical symptomatology relevant to the imaging findings. [...]