Critical Questions Regarding Gadolinium Deposition in the Brain and Body After Injections of the Gadolinium-Based Contrast Agents, Safety, and Clinical Recommendations in Consideration of the EMA’s Pharmacovigilance and Risk Assessment Committee Recommendation for Suspension of the Marketing Authorizations for 4 Linear Agents

This review focuses on 8 critical questions regarding gadolinium deposition in the brain and body, with the answers and discussion therein important for future regulatory decisions and clinical practice. [...]

Safety of the Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging, Focusing in Part on Their Accumulation in the Brain and Especially the Dentate Nucleus

This review discusses first the background in terms of development of these agents and safety discussions therein, proceeds to a discussion of NSF and gadolinium deposition in the brain, and concludes with a discussion of the predictable future – specifically reassessment of the use of the linear GBCAs or a subset thereof. [...]

Application of Extracellular Gadolinium-based MRI Contrast Agents and the Risk of Nephrogenic Systemic Fibrosis

Presented is a review of nephrogenic systemic fibrosis and how this influences daily practice (in contrast enhanced magnetic resonance imaging), with specific clinical recommendations. Download PPTX-zip [...]

Accelerating Clinical MRI in the 21st Century

The established class of intravenous contrast media for magnetic resonance imaging is the gadolinium chelates, more generally referred to as the gadolinium-based contrast agents (GBCAs). [...]

Magnetic Resonance Imaging and Computed Tomography of the Brain – 50 Years of Innovation, With a Focus on the Future

The established class of intravenous contrast media for magnetic resonance imaging is the gadolinium chelates, more generally referred to as the gadolinium-based contrast agents (GBCAs). [...]

Safety of the Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging, Focusing in Part on Their Accumulation in the Brain and Especially the Dentate Nucleus

The established class of intravenous contrast media for magnetic resonance imaging is the gadolinium chelates, more generally referred to as the gadolinium-based contrast agents (GBCAs). [...]

Val M. Runge, MD – Editorial – 50th anniversary issue of Investigative Radiology

ZURICH, May 12, 2015 — Val M. Runge, MD, editor-in-chief of Investigative Radiology, one of the world’s leading scientific journals in the field of imaging, previews in his editorial the upcoming anniversary issue of the journal. The 50th anniversary issue focuses on research (reflecting the very basis of the journal), specifically on the current top fields in clinical imaging, […] [...]

Val M. Runge, MD leads 50th anniversary issue of Investigative Radiology

ZURICH, April 6, 2015 /PRNewswire-iReach/ — Val M. Runge, MD, editor-in-chief of Investigative Radiology, one of the world’s leading scientific journals in the field of imaging, previews the upcoming anniversary issue of the journal. Scheduled to be published in September 2015, the issue includes 11 landmark articles, with the first already available on line (published ahead-of-print). (full […] [...]

Contrast Enhanced MRI

Contrast Enhanced MRI. Research Imaging Seminar. MD Anderson Center, June 21, 2012, Houston, Texas [...]

Gadolinium Contrast Agent Safety

Gadolinium Contrast Agent Safety. MR 2015 Garmisch (Germany), 16th International MRI Symposium. January 31, 2015 [...]

Contrast Agents: Optimization of Contrast-enhanced MRA

Ulrike I Attenberger, MD Department of Clinical Radiology and Nuclear Medicine University Medical Center Mannheim Mannheim, Germany  View Presentation [...]

Continuous Table Movement in MR Angiography – syngo Tim CT

Harald Kramer, MD Department of Clinical Radiology University Hospitals Munich – Grosshadern Munich, Germany [...]

Updates regarding GE, Omniscan, and Henrik Thomsen, MD Lawsuits

Henrik S. Thomsen M.D. Professor and Chairman Copenhagen University Hospital Department of Diagnostic Radiology Herlev, Denmark [...]

Latest on Nephrogenic Systemic Fibrosis (NSF)

Val M. Runge, M.D. Editor-in-Chief, Investigative Radiology   *Video: latest on nephrogenic systemic fibrosis (nsf) [...]

Contrast Agents: Nephrogenic Systemic Fibrosis (NSF)

Henrik S. Thomsen M.D. Professor and Chairman Copenhagen University Hospital Department of Diagnostic Radiology Herlev, Denmark [...]

Allergic Reactions to Gadolinium Chelates

“to date no prospective well-designed study has ever shown a significant difference in the reported adverse reaction rates among the available gadolinium chelates, either for nuisance reactions, such as headache or nausea, or for serious adverse events, such as anaphylaxis” [...]

Contrast Media Updates

Magnetic resonance contrast agents, in particular the gadolinium-based agents, are very safe and lack the nephrotoxicity (when injected intravenously) associated with iodinated contrast media. Minor adverse effects occur infrequently and include nausea, taste perversion, and hives. Whereas these agents cannot be differentiated on the basis of mild adverse effects, they do differ in regard to chelate stability, with clinical lab abnormalities known with the less stable agents. The issue of nephrogenic systemic fibrosis (NSF) and its relationship to the gadolinium chelates, and specifically their in vivo stability, is discussed in depth in the text that follows, together with recommendations for clinical practice. [...]

25 Years of Contrast in MRI, a Focus on the Patient (presented at the ECR 2013)

25 Years of Contrast in MRI, a Focus on the Patient (presented at the ECR 2013) View/Downloads PDF [...]

Nephrogenic Systemic Fibrosis (ACR Manual on Contrast Media v7)

Nephrogenic Systemic Fibrosis (ACR Manual on Contrast Media v7) [...]

Update on GE, Omniscan, and NSF, Jeff Gerth

Update on GE, Omniscan, and NSF, Jeff Gerth View/Download PDF [...]

Gadolinium Chelates with Extracellular Distribution

Gadolinium Chelates with Extracellular Distribution View/Download PDF [...]

The ACR Manual on Contrast Media

The ACR Manual on Contrast Media View/Download PDF [...]

The ESUR Manual on Contrast Media

The ESUR Manual on Contrast Media View/Download PDF [...]

Recognition and treatment of acute contrast reactions

Recognition and treatment of acute contrast reactions William H. Bush Jr., MD, FACR, and Arthur J. Segal, MD, FACR. Reprinted from Applied Radiology, Vol. 38, No. 12, Pages 16-21, Copyright 2009, with permission from Anderson Publishing Ltd. www.appliedradiology.com [...]

Contrast Agents: Safety Profile

Contrast Agents: Safety Profile View/Download PDF [...]