Detection and Characterization of Focal Liver Lesions using Respiratory-Triggered Diffusion- Weighted MR Imaging (DWI)

Due to a number of technical challenges, the use of DWI was initially confined to the brain with its low incidence of movement artifacts and the high homogeneity and signal-to-noise ratio (SNR) of brain tissue. Physiological motion artifacts (e.g. motility of the bowel, cardiac pulsation, respiratory motions) and the heterogeneous composition of many extracranial organs had precluded the application of DWI in body imaging until a series of technologic advances such as the development of echo-planar imaging (EPI), high-gradient amplitudes, multichannel coils and parallel imaging techniques enabled the acquisition of high quality diffusion-weighted images of the body.

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