Safety of the Gadolinium-Based Contrast Agents for Magnetic Resonance Imaging, Focusing in Part on Their Accumulation in the Brain and Especially the Dentate Nucleus

This review discusses first the background in terms of development of these agents and safety discussions therein, proceeds to a discussion of NSF and gadolinium deposition in the brain, and concludes with a discussion of the predictable future – specifically reassessment of the use of the linear GBCAs or a subset thereof.