Safety of the gadolinium chelates, high signal intensity in the dentate nucleus – a note from the editor, Val M. Runge, MD

A potentially very important issue is emerging, in terms of possible safety of the gadolinium chelates. Please refer to the two articles listed below.

  1. Errante Y, Cirimele V, Mallio CA, et al. Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is associated with cumulative doses of intravenously administered gadodiamide in patients with normal renal function, suggesting dechelation. Invest Radiol. 2014;49(10):685-90.
  2. Kanda T, Osawa M, Oba H, et al. High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration. Radiology. 2015:140364.